On April 12th, a study published in the latest issue of the international academic journal “Psychiatry and Clinical Neuroscience” showed that the commonly used drug for treating stroke, ibuprofen, can significantly improve the overall efficiency of the brain structural network in patients with mild cognitive impairment related to Alzheimer’s disease. This discovery provides new ideas for early intervention of cognitive impairment. Professor Wei Cuibai’s team from Xuanwu Hospital, Capital Medical University of China conducted a randomized, double-blind, placebo-controlled trial on 270 eligible subjects with mild cognitive impairment related to Alzheimer’s disease. The research team pointed out that brain network “disconnection” is an important pathological feature of Alzheimer’s disease. Butylphthalide may alleviate this disconnection state by restoring the efficiency of brain structural networks, thereby delaying cognitive decline. Revealing this mechanism has opened up new research directions for the treatment of Alzheimer’s disease.
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