On May 1st, the meningeal lymphatic system, as the “drainage network” of the brain, maintains homeostasis by clearing metabolic waste and transporting immune cells, but its developmental regulation mechanism has always been a mystery. Du Jiulin, a researcher at the Center for Excellence and Innovation in Brain Science and Intelligent Technology of the Chinese Academy of Sciences, discovered the brain regulation mechanism of meningeal lymphatic system development, that is, neural activity dynamically regulates the expression of key factors through specific glial cell subsets, and precisely controls the development of meningeal lymphatic endothelial cells under the cross organizational cooperation of meningeal fibroblasts. The relevant research results were published online on April 30th in the international academic journal Cell.
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